Oscar Hernandez, Ph.D.
Senior Regulatory Chemist
 

 
T: 202-557-3829
F: 202-557-3836
 
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EDUCATION:

B.Sc., Instituto Tecnologico y de Estudios Superiores de Monterrey (ITESM), Chemistry (Honors), 1970

Ph.D., University of Virginia, Chemistry, Organic Chemistry,1974

Post-doctoral Fellow, National Institutes of Health, 1974-1976

Post-doctoral Research, Mechanisms of Chemical Carcinogenesis and Polynuclear Aromatic Hydrocarbons, National Institute of Environmental Health Sciences, North Carolina, 1974-1976

 
 

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Oscar Hernandez, Ph.D., Senior Regulatory Chemist with The Acta Group (Acta®), is an exceptional resource for clients addressing chemical assessment and management issues under the Toxic Substances Control Act (TSCA) and other federal, state, and international chemical control authorities. Dr. Hernandez is the former Director of the Risk Assessment Division (RAD) in the U.S. Environmental Protection Agency's (EPA) Office of Pollution Prevention and Toxics (OPPT), where he managed a multi-disciplinary science group that provided expert scientific support in the areas of hazard and risk assessment of chemicals being reviewed pursuant to the regulatory programs OPPT implements.

During his 30-year career at EPA, Dr. Hernandez's chemical assessment activities included managing the TSCA Section 8(e) substantial risk reporting program; developing the initial HPV Challenge program and the subsequent development of Hazard Characterization documents; management of U.S. representation to the Organization for Economic Co-operation and Development's (OECD) Screening Information Data Set (SIDS); the Voluntary Children's Chemical Evaluation program (VCCEP); the Acute Exposure Guideline Levels (AEGL) program, a multi-agency program that generates air concentration levels for use by emergency response teams; Sustainable Futures, a program designed to help manufacturers develop new chemicals that are both economically and environmentally sustainable; assessment support to address national priority chemicals, including formaldehyde, lead, mercury, and perfluorinated chemicals; pioneering efforts in the assessment of nanomaterials; and more recently, the release of risk assessment documents of priority (Work Plan) chemicals.

Prior to his tenure at EPA, Dr. Hernandez worked in the private sector as a consultant, and conducted basic research on biological mechanisms of chemical carcinogenesis at the National Institute of Environmental Health Sciences (NIEHS). He holds a Ph.D. in Chemistry from the University of Virginia and complemented his education with a Post-doctoral Fellowship at the National Institutes of Health in Bethesda, Maryland. Dr. Hernandez continued to pursue his research interests on mechanisms of chemical carcinogenesis at NIEHS, Research Triangle Park, North Carolina. He is the author and co-author of numerous scientific publications based on the results of his research activities.

Professional & Community Involvement:

Member, American Chemical Society, 1972-present

Publications:

Books:

Lynn L. Bergeson, Charles M. Auer, Co-Editors; Timothy D. Backstrom, Lisa R. Burchi, Lisa M. Campbell, Sheryl L. Dolan, Richard E. Engler, Ph.D., Margaret R. Graham, Oscar Hernandez, Ph.D., Carla N. Hutton, Kathleen M. Roberts, Contributing Authors, New TSCA: A Guide to the Lautenberg Chemical Safety Act and Its Implementation, American Bar Association Section of Environment, Energy, and Resources (2017).

Articles:

Lynn L. Bergeson, James V. Aidala, Jr., Charles M. Auer, Richard Engler, and Oscar Hernandez, "Practitioner Insights: Enhancing TSCA Reform Implementation," Bloomberg BNA Daily Environment Report, August 2, 2017.

Lynn L. Bergeson, Charles M. Auer, Oscar Hernandez, "Creative Adaptation: Enhancing Oversight of Synthetic Biology Under the Toxic Substances Control Act," Industrial Biotechnology, October 2014.

Hernandez, O., Rhomberg, L., Hogan, K., Siegel-Scott, C., Lai, D., Grindstaff, G., Henry, M., and Cotruvo, J. A.(1994), "Risk assessment of formaldehyde", J. Hazardous Materials, 39, 161-172.

Hernandez, O., Pienta R. J., M. M. Jacobs, B. H. Chin, M. T. S. Hsia, J. M. DeSesso, and J. M. Kelley (1988), "Interim Draft Literature Review on VX," prepared for the U.S. Army Medical Research and Development Command, Contract No. DAMD17-86-C-6241, Control No. 3037, 87W00005, McLean, VA: The MITRE Corporation (DoD Classification: Secret).

Jacobs, M. M., O. Hernandez, R. J. Pienta, M. T. S. Hsia, B. H. Chin, J. M. DeSesso, and J. M. Kelley (1987), "Interim Draft Literature Review on GD (SOMAN)," prepared for the U.S. Army Medical Research and Development Command, Contract No. DAMD17-86-C-6241, Control No. 3037, 87W0001, McLean, VA: The MITRE Corporation (DoD Classification: Secret).

Reinert, J. C., A. P. Nielsen, C. Lunchick, O. Hernandez, and D. M. Mazzetta (1986), "The United States Environmental Protection Agency's Guidelines for Applicator Exposure Monitoring," Toxicologv Lett., 33, pp. 183-191.

DiAugustine, R. P., M. P. Walker, D. G. Klapper, R. I. Grove, W. D. Willis, D. J. Harvan, and O. Hernandez (1985), "Epidermal Growth Factor is the Desasparaginyl Form of the Polypeptide," J. Biol. Chem., 260, pp. 2807-2811.

Albro, P. W., C. E. Parker, G. D. Marbury, O. Hernandez, and F. T. Corbin (1984), "Spectrometric Characterization of Metribuzin and its Metabolites," Appl. Spectrosc., 38, pp. 556-562.

Foureman, G. L., C. Harris, O. Hernandez, A. Bhatia, and J. R. Beud (1984), "Stereoselectivity in the Microsomal Cytochrome P-450 Dependent Oxidation of Styrene to Styrene 7,8-0xide," Toxicologist, 4, p. 142.

Hernandez, O., K. Dermott, and L. Lazarus (1984), "High-Performance Liquid Chromatography of Amphibian Peptides. Selectivity Changes Induced by pH," J. Liquid Chromatgr., 7, pp. 893-905.

Hernandez, O. and M. B. Gopinathan (1984), "Synthesis of Glutathione Adducts of K-Region Arene Oxides," J. Chem. Soc. Chem. Commun., pp. 1491-1492.

Yagen, B., Z. Ben-Zvi, G. L. Foureman, A. U. Ryan, O. Hernandez, R. H. Cox, and, U. R. Bend (1984), "Metabolism and Excretion of Glutathione Conjugates of 14C-styrene Oxide by the Winter Flounder, P: americaus, a Marine Teleost: Identification of the Corresponding S-Cysteine Derivatives as Major Urinary Metabolites," Drug and Metab. Dispos., 12, pp. 389-395.

Buening, M. K., W. Levin, A. W. Wood, R. L. Chang, I. Agranat, M. Rabinovitz, D. R. Buhler, H. D. Mah, O. Hernandez, R. B. Simpson, D. M. Jerina, A. H. Conney, E. C. Miller, and J. A. Miller (1983), "Fluorine Substitution as a Probe for the Role of the 6-Position of Benzo[a]pyrene in Carcinogensis," J. Natl. Cancer Inst., 71, pp. 309-317.

Hernandez, O., A. V. Bhatia, and M. P. Walker (1983), "HPLC Separation of the Diastereomeric Glutathione Adducts of Styrene Oxide," J. Liquid Chromatogr., 6, pp. 1476-1489.

Hernandez, O., A. V. Bhatia, and M. P. Walker (1983), "HPLC Separation of Diastereomeric Adducts of Glutathione with some K-Region Arene Oxides," J. Liquid Chromatogr., 6, pp. 1693-1704.

Hernandez, O. and K. K. Kohli (1983), "Removal of the Nonionic Detergent Emulgen 911 from Solubilized Microsomes by HPLC", J. Liquid Chromatogr., 6, pp. 1459-1473.

Lazarus, L. H., R. P. DiAugustine, G. D. Jahnke, and O. Hernandez (1983), "Physalaemin: An Amphibian Tachykanin in Human Lung Small-Cell Carcinoma," Science, 219, 79-81.

Erisman, M. D., R. I. Linnoila, O. Hernandez, R. P. DiAugustine, and L. H. Lazarus (1982), "Evidence of Bombesin in a Human Oat-Cell Carcinoma," Proc. Natl. Acad. Sci. U.S.A., 79, pp. 2379-2383.

Hernandez, O., B. Yagen, R. H. Cox, J. R. Bend, and J. D. McKinney (1982), "HPLC Analysis of the Isomeric Thioether Metabolites of Styrene Oxide," J. Liquid Chromatogr., 5, pp. 345-365.

Kohli, K. K., O. Hernandez, and J. D. McKinney (1982), "Fractionation by HPLC of Microsomal Cytochrome P-450 Induced by Hexachlorobiphenyl Isomers," J. Liquid Chromatogr., 5, pp. 367-377.

Pagano, D. A., B. Yagen, O. Hernandez, J. R. Bend, and E. Zeiger (1982), "Mutagenicity of (R)- and (S)- Styrene 7,8-Oxide and the Intermediary Mercapturic Acid Metabolites Formed from Styrene 7,8-Oxide," Environ. Mutagen., 4, pp. 575-584.

Hernandez, O., S. K. Chaudhary, R. H. Cox, and J. Porter (1981), "Synthesis and Characterization of 4-Dimethylamino-N-Triphenylmethylpyridinium Chloride: A Postulated Intermediate in the Tritylation of Alcohols," Tetrahedron Lett., 22, pp. 1491-1494.

Hernandez. O., G. L. Foureman, R. H. Cox, J. R. Bend, M. Walker, and B. R. Smith (1981), "Stereo- and Regioselectivity in the Enzymatic Conjugation of Glutathione with (+)-Benzo[a]pyrene 4,5-0xide," International Symposium on Polynuclear Aromatic Hydrocarbons, Battelle Laboratories, Columbus, OH: Battelle Press, pp. 667-674.

Steele, V. W., B. Yagen, O. Hernandez, R. H. Cox, B. R. Smith, and J. R. Bend (1981), "The Metabolism and Excretion of Styrene Oxide¬Glutathione Conjugates in the Rat by Isolated Perfused Liver, Lung and Kidney Preparations," J. Pharmacol. Exp. Ther., 219, pp. 35-41.

Yagen, B., O. Hernandez, J. R. Bend, and R. H. Cox (1981), "Synthesis and Relative Stereochemistry of the Benzylic Thioether Diastereomers Formed from Glutathione and Styrene Oxide," Biorg. Chem., 10, pp. 299-310.

Yagen, B., O. Hernandez, J. R. Bend, and R. H. Cox (1981), "Synthesis and Relative Stereochemistry of the Four Mercapturic Acids Derived from Styrene Oxide and N-Acetylcystein," Chem. Biol. Interact., 34, pp. 57-67.

Cox, R. H., O. Hernandez, B. Yagen, B. R. Smith, J. D. McKinney, and J. R. Bend (1980), "13C NMR Studies of the Structure and Stereochemistry of Products Derived from the Conjugation of Glutathione with Alkene and Arene Oxides," The Chemistry of Environmental Agents as Potential Human Hazard, J. D. McKinney, ea., Ann Arbor, MI: Ann Arbor Science Publishers, Inc., pp. 403-423.

Hernandez, O., J. R. Bend, T. E. Eling, and J. D. McKinney (1980), "Optically-Pure Thromboxanes (U.S. Patent 4,256,646)," Chem. Abstracts, 93, pp. 460-592.

Hernandez, O., M. Walker, R. H. Cox, G. L. Foureman, B. R. Smith, and J. R. Bend (1980), "Regiospecificity and Stereospecificity in the Enzymatic Conjugation of Glutathione with (+)-Benzo[a]pyrene 4,5-Oxide," Biochem. Biophys. Res. Commun., 96, pp. 1494-1502.

Hernandez, O., B. Yagen, R. H. Cox, B. R. Smith, G. L. Foureman, J. R. Bend, and J. D. McKinney (1980), "Stereospecificity and Regioselectivity in the Reaction of Epoxides with Glutathione," The Chemistry of Environmental Agents as Potential Human Hazard," J. D. McKinney, ea., Ann Arbor, MI: Ann Arbor Science Publishers, Inc., pp. 425-444.

Lazarus, L. H., R. I. Linnoila, O. Hernandez, and R. P. DiAugustine (1980), "A Neuropeptide in Mammalian Tissues with Physalaemin-Like Immunoreac¬tivity," Nature, 287, pp . 555-558.

Chaudhary, S. K. and O. Hernandez (1979), "A Simplified Procedure for the Preparation of Triphenylmethylethers," Tetrahedron Lett., pp. 95-98.

Chaudhary, S. K. and O. Hernandez (1979), "4-Dimethylaminopyridine: An Efficient and Selective Catalyst for the Silylation of Alcohols," Tetrahedron Lett., pp . 99-102.

Cox, R. H., O. Hernandez, J. W. Dorner, R. J. Cole, and I. D. Fennel (1979), "A New Isochram Mycotoxin Isolated from Penicillium steckii," J. Agric. Food Chem., 27, pp. 999-1001.

Cutler, H. G., F. G. Crumley, R. H. Cox. O. Hernandez, R. J. Cole, and J. W. Dorner (1979), "Orlandin: A Nontoxic Fungal Metabolite with Plant Growth Inhibiting Properties," J. Agric. Food Chem., 27, pp. 592-595.

Bryan, R. F., F. A. Carey, O. Hernandez, and I. F. Taylor (1978), "Effect of 2-Triphenylsilyl Substitution on the Molecular Geometry of 1,3-Dithianes," J. Org. Chem., 43, pp. 85-90.

Hernandez, O. (1978), "Chiral Synthesis of Thromboxane B2 Intermediates," Tetrahedron Lett., pp . 219-222.

Regan, J. D., A. A. Francis, W. C. Dunn, O. Hernandez, H. Yagi, and D. M. Jerina (1978), "Repair of DNA Damaged by Mutagenic Metabolites of Benzo[a]pyrene in Human Cells," Chem.-Biol. Interact., 20, pp. 279-287.

Jerina, D. M., H. Yagi, and O. Hernandez (1977), "Stereoselective Synthesis and Reactions of a Diol-Epoxide", Biological Reactive Intermediates, D. Jalow, J. Kocsis, R. Snyder, and H. Vainio, eds., New York: Plenum Press, pp. 371-378.

Wislocki, P. G., R. L. Chang, A. W. Wood, W. Levin, H. Fagi, O. Hernandez, H. D. Mah, P. M. Dansette, D. M. Jerina, and A. H. Conney (1977), "High Carcinogenicity of 2-Hydroxybenzo(a)pyrene on Mouse Skin," Cancer Res., 37, pp. 2608-2611.

Yagi, H., D. Thakker, O. Hernandez, M. Koreeda, and D. M. Jerina (1977), "Synthesis and Reactions of the Highly Mutagenic Diol Epoxides of the Environmental Carcinogen Benzo[a]pyrene," J. Am. Chem. Soc., 99, pp. 1604-1611.

Carey, F. A., O. D. Dailey, Jr., and O. Hernandez (1976), "The Stereoselectivity of Reactions of Electrophilic Species with 2-Lithio-l, 3-Dithiane 1-Oxide," J. Org. Chem., 41, pp. 3979-3983.

Carey, F. A., O. D. Dailey, Jr., O. Hernandez, and J. R. Tucker (1976), "Stereoselective Synthesis of Cis and Trans-2-substituted-1,3-dithiane 1-oxides," J. Org. Chem., 41, pp. 3975-3978.

Jerina, D. M., R. E. Lehr, H. Yagi, O. Hernandez, P. M. Dansette, P. G. Wislocki, A. W. Wood, R. L. Chang, W. Levin, and A. H. Conney (1976), "Mutagenicity of Benzo[a]pyrene Derivatives and the Description of a Quantum Mechanical Model Which Predicts the Ease of Carbonium Ion Formation from Diol Epoxides," In Vitro Activation in Mutagenesis Testing, F. J. deSerres, J. R. Fouts, J. R. Bend, and R. M. Philpot, eds., Amsterdam, Netherlands: Elsevier, pp. 159-177.

Jerina, D. M., H. Yagi, O. Hernandez, P. M. Dansette, A. W. Wood, W. Levin, R. L. Chang, P. G. Wislocki, and A. H. Conney (1976), "Synthesis and Biological Activity of Potential Benzo[a]pyrene Derivatives,n Symposium on Polynuclear Aromatic Hydrocarbons, Battelle Laboratories, Columbus, Ohio; New York: Raven Press, pp. 91-113.

Wislocki, P. G., A. W. Wood, R. L. Chang, W. Levin, H. Yagi, O. Hernandez, P. M. Dansette, D. M. Jerina, and A. H. Conney (1976), "Mutagenicity and Cytotoxicity of Benzo[a]pyrene Arene Oxides, Phenols, Quinones, and Dihydrodiols in Bacterial and Mammalian Cells," Cancer Res., 36, pp. 3350-3357.

Wislocki, P., A. Wood, R. Chang, W. Levin, H. Yagi, O. Hernandez, D. Jerina, and A. Conney (1976), "High Mutagenicity and Toxicity of a Diol Epoxide Derived from Benzo[a]pyrene," Biochem. BioDhys. Res. Commun., 68, pp. 1006-1012.

Wood, A. W., W. Levin, A. Y. H. Lu, A. H. Conney, H. Yagi, O. Hernandez, and D. M. Jerina (1976), "Use of a Highly Purified Hepatic Microsomal Monooxygenase System and Epoxide Hydrase to Metabolically Activate and Deactivate Benzo[a]pyrene and Benzo[a]pyrene Derivates," In Vitro Activation in Mutagenesis Testing, F. J. deSerres, J. R. Fouts, J. R. Bend, and R. M. Philpot, eds., Amsterdam, Netherlands: Elsevier, pp. 179-195.

Wood, A. W., W. Levin, A. Y. H. Lu, H. Yagi, O. Hernandez, D. M. Jerina, and A. H. Conney (1976), "Metabolism of Benzo[a]pyrene and Benzo[a]pyrene Derivatives to Mutagenic Products by Highly Purified Hepatic Microsomal Enzymes," J. Biol. Chem., 251, pp. 4882-4890.

Wood, A. W., P. G. Wislocki, R. L. Chang, W. Levin, H. Yagi, O. Hernandez, D. M. Jerina, and A. J. Conney (1976), "Mutagenicity and Cytotoxicity of Benzo[a]pyrene Benzo-ring Epoxides," Cancer Res., 36, pp. 3358-3366.

Yagi, H., G. M. Holder, P. M. Dansette, O. Hernandez, H. J. C. Yeh, R. A. Le Mahieu, and D. M. Jerina (1976), nSynthesis and Spectral Properties of the Isomeric Hydrobenzo[a]pyrenes," J. Org. Chem., 41, pp. 977-985.

Kahn, S. A., J. B. Lambert, O. Hernandez, and F. A. Carey (1975), "Oxides of 1,3-Dithiane and 1,3,5-Trithiane. The Diamagnetic Anisotropy of Carbon¬Sulfur Bonds," J. Am. Chem. Soc.,, 97, pp. 1468-1473.

Yagi, H., O. Hernandez, and D. M. Jerina (1975), "Synthesis of (+)-7b, 8a¬Dihydroxy-9,10 Epoxy-7,8,9,10-Tetrahydrobenzo!alpyrene, a Potential Metabolite of the Carcinogen Benzo[a]pyrene with Stereochemistry Related to the Antileukemic Triptolides," J. Am. Chem. Soc., 97. pp. 6881-6883.

Carey, F. A. and 0. Hernandez (1973), "Silicon-Containing Carbanions. III. Synthesis of Vinyl Sulfoxides via 1-trimethylsilyl-1-(phenyl-sulfinyl) Methyllithium," J. Org. Chem., 38, pp. 2670-2675.

Speaking Engagements:

Bend, J. R., C. Harris, R. M. Philpot, and 0. Hernandez, "Stereoselectivity in the Cytochrome P-450 Dependent Conversion of Styrene to Styrene 7,8-oxide by Microsomal and Reconstituted Monooxygenase Systems," 6th International Symposium on Microsomes and Drug Oxidations, Brighton Sussex, UK (August, 1984).

DiAugustine, R. P., M. P. Walther, O. Hernandez, R. S. Grove, and R. M. Praft, "Multiple Forms of Epidermal Growth Factor," 65th Annual Meeting, The Endocrine Society (1983).

Hernandez, O., M. B. Gopinathan, and M. Browder, "Synthesis of Intermediates in the Metabolic Detoxication of Epoxides. Mercapturic Acid Derivatives of Athene and Arene Oxides," 186th ACS National Meeting, Washington, D.C. (August, 1983).

Harris, C., O. Hernandez, A. Bhatia, B. Yagen, and J. R. Bend, "Stereoselectivity and Regioselectivity of Rat Liver Glutathione Transferases with Styrene 7,8-Oxide as Substrate," Society of Toxicology (1982).

Hernandez, O., A. Bhatia, G. Foureman, M. Walther, and J. R. Bend, "Synthesis and Stereochemical Analysis of Glutathione Adducts of Arene Oxides," 184th ACS National Meeting, Kansas City, Missouri (September, 1982).

Harvan, D. J., B. Yagen, O. Hernandez, and J. R. Hass, "Mass Spectrometry of Glutathione, Cysteine, and Mercapturic Acid Conjugates of Styrene Oxide," 29th Annual Conference on Mass Spectrometry and Allied Topics, Minneapolis, Minnesota (July, 1981).

Hernandez, O., G. L. Foureman, R. H. Cox, J. R. Bend, M. Walker, and B. Smith, "Stereo--and Regioselectivity in the Enzymatic Conjugation of Glutathione with (+)-benzo[a]pyrene 4,5-Oxide," 5th International Symposium on Polynuclear Aromatic Hydrocarbons, Columbus, Ohio (October, 1980).

Yagen, B., O. Hernandez, J. R. Bend, and R. H. Cox, "Synthesis and Stereochemistry of the Glutathione and Mercapturic Acid Conjugates of Styrene Oxide," ACS Southeast/Southwest Regional Meeting (December, 1980).

Cox, R. H., O. Hernandez, B. Yagen, and B. Smith, ''13G NMR Studies of the Structure and Stereochemistry of Products Derived from Glutathione Transferase Reactions with Arene Oxides," 178th ACS National Meeting, Washington, D.C. (September, 1979).

Hernandez, O., B. Yagen, R. H. Cox, B. Smith, G. L. Foureman, J. R. Bend, and J. D. McKinney, "Stereospecificity and Regioselectivity in the Enzymatic Conjugation of Glutathione with Epoxides," 178th ACS National Meeting, Washington, D.C. (September, 1979).

Hernandez, O., S. Chaudhary, and R. H. Cox, "Salts of 4-Dimethyl-aminopyridine. Reagents for Selective Protecting Groups," 30th Southeast Regional Meeting ACS (November, 1978).

Hernandez, O., R. H. Cox, B. R. Smith, J. R. Bend, and J. D. McKinney, "Structural Properties and Synthesis of Glutathione Conjugates of Oxides of Styrene and Benzo[a]pyrene," 3rd International Symposium on Polynuclear Aromatic Hydrocarbons, Columbus, Ohio (October, 1978).

Hernandez, O., "Chiral Synthesis of Thromboxane B2 from D-Glucose," 29th Southeastern Regional Meeting ACS (November, 1977).


 
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