Christine M. Palermo, Ph.D., DABT

Representative Engagements

• Advised a global technology and manufacturing company on international chemical compliance requirements, including substance registration strategies, classification and labeling, supply chain communication, and approaches to addressing differing regulatory requirements across jurisdictions.
• Advised a global distributor in assessing the scope and applicability of EU chemicals and product legislation, including the scope and applicability of Restriction of Hazardous Substances (RoHS) substance restrictions and Conformité Européenne (CE) marking and conformity assessment requirements for products placed on the EU market.
• Assisted a U.S.-based chemicals supplier in EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) and comparable chemical regulatory data-compensation matters, including valuation of regulatory data, negotiation of data sharing arrangements, and preparation and negation of Letters of Access (LoA) and related agreements.
• Managed EU REACH, South Korea Act on the Registration and Evaluation of Chemicals (K-REACH), and Turkey Kimyasalların Kaydı, Değerlendirilmesi, İzni ve Kısıtlanması (KKDIK) obligations for a global chemical supplier through Only Representative (OR) arrangements, including assessment of registration requirements, submission of registration dossiers, management of ongoing compliance obligations, and engagement with supply chain stakeholders.

Articles and Writings

• Lea IA, Buerger AN, Feifarek D, Mihalchik A, Heintz MM, Haws LC, Nyambego H, Goyak K, Palermo C, Borghoff SJ. 2024. Evaluation of the endocrine disrupting potential of di-isononyl phthalate.

• Lea IA, Feifarek D, Mihalchik A, Heintz M, Haws L, Nyambego H, Goyak K, Palermo C, Borghoff SJ. 2024. Evaluation of the endocrine disrupting potential of di-isodecyl phthalate.

• Rogers JM, Buerger AN, Palermo C, Heintz MM, Haws LC, Lea IA. 2024. Evaluation of a Sertoli cell based adverse outcome pathway for effects of DINP on the developing male reproductive tract.

• Palermo CM, Foreman JE, Wikoff DS, Lea I. 2021. Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific considerations for the androgen sensitive window of development. Curr Res Toxicol. 2:254-271. doi: 10.1016/j.crtox.2021.07.002.

• van den Driesche S, Shocker S, Palermo C, Inglis F, Langsh A, Otter R. 2020. Systematic comparison of the male reproductive tract in fetal and adult Wistar rats exposed to DBP and DINP in utero during the masculinisation programming window. Toxicology letters 335:37-50. https://doi.org/10.1016/j.toxlet.2020.10.006.

• Morfeld P, Chen M, Otter R, Palermo C, Kemmerling J, Mastrantonio M. 2017. Boberg et al. (2011) — Corrigendum (2016): Further significant modifications needed. Reproductive Toxicology. 71:159-161. doi.org/10.1016/j.reprotox.2017.03.013.

• Chen M, Alyea R, Morfeld P, Otter, R, Kemmerling J, Palermo C. 2017. Reproducibility discrepancies following reanalysis of raw data for a previously published study on diisononyl phthalate (DINP) in rats. Data in Brief. 13:208-213. doi.org/10.1016/j.dib.2017.05.043.

• Becker RA, Dellarco V, Seed J, Kronenberg JM, Meek B, Foreman J, Palermo C, Kirman C, Linkov I, Schoeny R, Dourson M, Pottenger LH, Manibusan MK. 2017. Quantitative weight of evidence to assess confidence in potential modes of action. Reg. Tox. Pharm. 86:205-220. https://doi.org/10.1016/j.yrtph.2017.02.017.

• Moore NP, Beekhuijzen M, Boogaard PJ, Foreman JE, North CM, Palermo C, Schneider S, Strauss V, van Ravenzwaay B, Poole, A. 2016. Guidance on the selection of cohorts for the extended one-generation reproduction toxicity study (OECD test guideline 443). Reg. Tox. Pharm. 80:32-40. https://doi.org/10.1016/j.yrtph.2016.05.036.

• Bette Meek ME, Palermo CM, Bachman AN, North CM, Jeffrey Lewis R. 2014. Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence. Appl Toxicol. 34(6):595-606. doi: 10.1002/jat.2984.

• Greim H, Kaden DA, Larson RA, Palermo CM, Rice JM, Ross D, Snyder R. 2014. The bone marrow niche, stem cells, and leukemia: impact of drugs, chemicals, and the environment. Ann N Y Acad Sci. 1310(1):7-31. doi: 10.1111/nyas.12362.

• Ahsan SA, Lackovic M, Katner A, Palermo C. 2009. Metal fume fever: a review of the literature and cases reported to the Louisiana Poison Control Center. The J. La State Med Soc. 161:348-51.

• Palermo CM, Bennett CA, Winters AC, Hemenway CS. 2008. The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells. Leuk Res. 32(4):633-42. doi: 10.1016/j.leukres.2007.08.002.

• Palermo CM, Westlake CA, Gasiewicz TA. 2005. Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein. Biochemistry. 44(13):5041-52. doi: 10.1021/bi047433p.

• Joiakim A, Mathieu PA, Palermo C, Gasiewicz TA. Reiners JJ. 2003. The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor. Drug Metab. Dispos. 31(11):1279-82. doi: 10.1124/dmd.31.11.1279.

• Zhou JG, Henry EC, Palermo CM, Dertinger SD, Gasiewicz TA. 2003. Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements. Mol Pharmacol. 63(4):915-24. doi: 10.1124/mol.63.4.915.

• Palermo CM, Martin Hernando JI, Dertinger SD, Kende AS, Gasiewicz TA. 2003. Identification of potential aryl hydrocarbon receptor antagonists in green tea. Chem Res Toxicol. 16(7):865-72. doi: 10.1021/tx025672c.